“Isoda yo guteka (Sodium Bicarbonate) idahumanya kandi idatera ikibazo iba iri mu gice cy’umusemburo (liposome) gitekanye, maze tetracycline ifite imbaraga zo gufata amagufwa ishyirwa hejuru kugira ngo yinjire ku buso bw’amagufwa. Iyo osteoclast yangije ingirangingo z’amagufwa isohora aside, ishobora guhita irekura Sodium Bicarbonate, ikabuza imikorere ya osteoclast no kugera ku ntego yo gukumira indwara ya osteoporosis by’umwihariko.” Itsinda riyobowe na Porofeseri Shunwu Fan wo mu ishami ry’amagufwa, Ibitaro bya Run Run Shaw, Kaminuza ya Zhejiang, na Porofeseri Ruikang Tang wo mu ishami ry’ubutabire, Kaminuza ya Zhejiang, baherutse gushyira ahagaragara ibyo bavumbuye mu kinyamakuru cya American Chemical Society.
Dukurikije intangiriro, osteoclast ni nk'inyenzi mu giti, iyo zabaga zikora, ndetse n'igiti kirekire, ariko nanone bitewe no kubora no kugwa igihe kirekire. Ubushakashatsi buriho bwerekana ko impamvu nyamukuru itera osteoclast ari ugukora ku buryo budasanzwe kwa osteoclast, kandi imisemburo ya aside ituruka kuri osteoclast ifatwa nk'ikintu cy'ingenzi gituma amagufwa yangirika bitewe n'amagufwa ya osteoclast, kandi ni ngombwa ko ingirabuzimafatizo zayo zingirika.
Imiti y'ingenzi mu kuvura indwara ya osteoporosis igera ku ntego yo kurwanya imitsi yo mu magufwa no guteza imbere uburyo amagufwa akoreshwa mu gukora osteoclast cyangwa osteoblast, ariko ntiyica intambwe y'ingenzi y'imiterere y'aside yo hanze y'irema rya osteoclast iturutse aho ikomoka. Kubwibyo, imiti isanzwe ishobora kugabanya umuvuduko w'amagufwa ku rugero runaka, ariko akenshi ntishobora gusubiza inyuma burundu iyangirika ry'amagufwa ryabayeho, kandi gutanga imiti itari iy'amagufwa bishobora no gutera ingaruka mbi ku ngingo zitari izabo n'izindi.
Byongeye kandi, nubwo osteoclasts ari yo mpamvu itera osteoporosis, ubushakashatsi bwinshi bwagaragaje ko bigira uruhare mu gutuma amagufwa avuka ndetse no gutera angiogenesis nk'"uturemangingo tw'ibanze" mbere yo gusohora aside. Kubwibyo, ni ngombwa cyane gukumira osteoclasts neza.
Ikipe ya Fan Shunwu n'ikipe ya Tang Ruikang ni bo batangije igikorwa cyo kwibasira liposomes za Sodium Bicarbonate ku buso bw'amagufwa, bakora urwego rurinda alkaline, bagabanya aside ivanwa mu magufwa, babuza osteoclasts gukora ku buryo budasanzwe, kandi bongera guhindura imiterere y'ibidukikije by'amagufwa kugira ngo bagere ku ngaruka zo kuvura osteoporosis.
Lin Xianfeng, umuganga w’inzobere mu kubaga amagufwa mu bitaro bya Run Run Shaw bya Kaminuza ya Zhejiang, yavuze ko ubushakashatsi bwagaragaje ko ibikoresho bya alkaline liposome hamwe n’ibidukikije bya aside byo mu magufwa byateraga umubare munini wa osteoclasts, ndetse bikanarekura umubare munini wa vesicles zo hanze y’umubiri.
Igihe cyo kohereza: Mutarama-27-2021